Nerve Conduction Physiology

Nerve Conduction Physiology BASIC PHYSIOLOGY OF NERVE CONDUCTION The neurons form the building blocks of the nervous system. The central nervous system (CNS) contains about 100 billion neurons. It also contains 10–50 times this number of glial cells. Neurons Neurons in the mammalian central nervous system come in many different shapes and sizes. Most of them have the same parts as a typical spinal motor neuron shown in Figure 2. Figure-2: Typical spinal motor neuron The cell body (soma) contains the nucleus and is the metabolic center of the neuron. Neurons have processes known as dendrites which extend outward from the cell body and arborize extensively. Particularly in the cerebral and cerebellar cortex, the small knobby projections over dendrites are called dendritic spines. The dendrites are the receptive part of the neuron. A typical neuron has long fibrous axon that originates from thickened area of the cell body, the axon of hillock. The first portion of the axon is called the initial segment. The axon divides into presynaptic terminals, each ending in a number of synaptic knobs which are also called terminal buttons or boutons. They contain granules or vesicles in which the synaptic transmitters secreted by the nerves are stored. The axonal process is responsible for transmission of propagated impulses to the nerve endings. Based on the number of processes that emanate from their cell body, neurons can be classified as unipolar, bipolar, and multipolar. Figure-3: Unipolar and bipolar neurons Figure-4: Multipolar neurons Glial cells: There are two major types of glial cells : microglia and macroglia. Microglia are scavenger cells they resemble tissue macrophages and remove debris resulting from injury, infection, and disease (eg, multiple sclerosis, AIDS-related dementia, Parkinson disease, and Alzheimer disease). Microglia arise from macrophages outside the nervous system and are physiologically and embryologically unrelated to other neural cell types. Glial cells continue to undergo cell division even in adults and their ability to proliferate is particularly noticeable after brain injury (eg, stroke). There are three types of macroglia: 1 Oligodendrocytes, 2 Schwann Cells, and 3 Astrocytes. Oligodendrocytes and Schwann cells form myelin around axons in the CNS and PNS , respectively. Astrocytes are of two subtypes. Fibrous astrocytes, which contain intermediate filaments, found primarily in white matter. Protoplasmic astrocytes are found in gray matter having granular cytoplasm. Both types of astrocytes send processes to blood vessels, where they induce capillaries forming the tight junctions making up the blood–brain barrier. They send processes enveloping synapses and surface of nerve cells. Protoplasmic astrocytes have a membrane potential varying with the external K+ concentration but they do not generate propagated potentials. They produce substances that are tropic to neurons, and they help maintain the appropriate concentration of ions and neurotransmitters by taking up K+ and the neurotransmitters glutamate and ÃŽ ³-aminobutyrate (GABA). The axons of many neurons are myelinated, that is, they acquire myelin sheath, a complex of protein lipid wrapped around axon. In the peripheral nervous system, when a Schwann cell wraps its membrane around an axon up to 100 times myelin is formed. The myelin is then compacted when the extracellular portions of a membrane protein called protein zero (P0) lock to the extracellular portions of P0 in the apposing membrane. The axon is covered by myelin sheath except at the ending and at the nodes of Ranvier, periodic 1-m constrictions that are about 1 mm apart (Barrett et al., 2012). In the myelinated neurons, the junction between the 2 Schwann cells is known as the node of Ranvier, where the axon remains uninsulated. The intermodal distance is the distance between the 2 nodes of Ranvier and depends upon the spacing of Schwann cells at the time of myelination. As there is no proliferation of Schwann cells later on, intermodal distance increases during the growth of nerve. Thus the fibe rs myelinated early have longer intermodal distance, larger diameter and wider spacing at the node of Ranvier. The nerve conduction velocity depends on the fiber diameter and intermodal distance. The larger the axon the thicker the myelin sheath and longer the internodal distance, the faster the conduction velocity. (Mishra Kalita, 2006). Not all neurons are myelinated; some are unmyelinated, that is, simply surrounded by Schwann cells without the wrapping of the Schwann cell membrane that produces myelin around the axon. Figure-5: Glial cells: A Oligodendrocyte, B Schwann Cell, C Astrocyte Most of the neurons are myelinated in the CNS of mammals,, but the cells that form the myelin are oligodendrocytes rather than Schwann cells. Unlike the Schwann cell, which forms the myelin between two nodes of Ranvier on a single neuron, oligodendrocytes emit multiple processes that form myelin on many neighboring axons. Generation and conduction of impulse in nerve cells Nerve cells have a low threshold for excitation responding to electrical, chemical, or mechanical stimulus. Two types of physicochemical disturbances are produced and these are the only electrical responses of neurons and other excitable tissues,. local, non propagated potentials; and propagated potentials, the action potentials (or nerve impulses) and they are the main language of the nervous system. They are produced by alterations in ion channels causing changes in the conduction of ions across the cell membrane. These electrical events are rapid, measured in milliseconds (ms); and the potential changes are small, being measured in millivolts (mV). The impulse is normally transmitted (conducted) along the axon to its termination. Conduction of nerve impulses is rapid but much slower than that of electricity. Conduction is an active process it is self-propagating , and the impulse moves at a constant amplitude and velocity. Resting membrane potential The resting membrane potential represents an equilibrium situation at which the driving force for the membrane-permeant ions down their concentration gradients across the membrane is equal and opposite to the driving force for these ions down their electrical gradients. In neurons, the concentration of K+ is much higher inside than outside the cell, while the reverse is the case for Na+. This concentration difference is established by the Na+K+ ATPase. In neurons, the resting membrane potential is usually about –70 mV, which is close to the equilibrium potential for K+. Action potential In response to a depolarizing stimulus, some of the voltage-gated Na+ channels become active, and when the threshold potential is reached, the voltage-gated Na+ channels overwhelm the K+ and other channels and an action potential results (a positive feedback loop). The membrane potential moves toward the equilibrium potential for Na+ (+60 mV) but does not reach it during the action potential, primarily because the increase in Na+ conductance is short-lived. The sodium ion channels rapidly get closed called the inactivated state .In addition, the direction of the electrical gradient for Na+ is reversed during the overshoot because the membrane potential is reversed, and this limits Na+ influx. A third factor producing repolarization is the opening of voltage-gated K+ channels. This opening is slower and more prolonged than the opening of the Na+ channels, and consequently, much of the increase in K+ conductance comes after the increase in Na+ conductance. The net movement of positive charge out of the cell due to K+ efflux at this time helps complete the process of repolarization. The slow return of the K+ channels to the closed state also explains the after-hyperpolarization, followed by a return to the resting membrane potential. Thus, voltage-gated K+ channels bring the action potential to an end and cause closure of their gates through a negative feedback process. Distribution of Ion Channels in Myelinated Neurons The spatial distribution of ion channels along the axon plays a key role in the initiation and regulation of the action potential. Voltage-gated Na+ channels are highly concentrated in the nodes of Ranvier and the initial segment in myelinated neurons. The initial segment and, in sensory neurons, the first node of Ranvier are the sites where impulses are normally generated, and the other nodes of Ranvier are the sites to which the impulses jump during saltatory conduction which is responsible for faster impulse conduction in myelinated neurons. The number of Na+ channels per square micrometer of membrane in myelinated mammalian neurons has been estimated to be 50–75 in the cell body, 350–500 in the initial segment, less than 25 on the surface of the myelin, 2000–12,000 at the nodes of Ranvier, and 20–75 at the axon terminals. Along the axons of unmyelinated neurons, the number is about 110. Electrogenesis of the Action Potential The nerve cell membrane is polarized at rest, with positive charges lined up along the outside of the membrane and negative charges along the inside. During the action potential, this polarity is abolished and for a brief period is actually reversed. Positive charges from the membrane ahead of and behind the action potential flow into the area of negativity represented by the action potential (current sink). By drawing off positive charges, this flow decreases the polarity of the membrane ahead of the action potential. Such electrotonic depolarization initiates a local response, and when the firing level is reached, a propagated response occurs that in turn electrotonically depolarizes the membrane in front of it. (Barrett et al., 2012) Figure-6: Propagation of Action Potential Action potential generated in axons is propagated to either direction from its site of origin. Intracellular current flows from the active zone where the inner cell membrane is positively charged compared to adjacent inactive membrane which is negatively charged. An opposing current flows through the extracellular fluid from the inactive to active region. This local current depolarizes the adjacent inactive regions, thus resulting in impulse propagation bidirectionally along the axon. The physiologic impulses, however, arise at one end of the axon i.e., the cell body or sensory terminal and are conducted only orthodromically. In pathological conditions, however, this order of conduction is not maintained. In the myelinated fibers, the conduction is much faster than the unmyelinated. In normal myelinated axons the impulse propagated by saltatory conduction. Saltatory conduction has been compared with a kangaroo travelling at speed. The action potential advance at near uniform velocity , but it is powered by discrete kicks of inward membrane current at the nodes of Ranvier. For rapid conduction, the intermodal distance should be great enough to maximize the jump of the action potential and reduce the loss of current at the node of Ranvier. In myelinated fibers the time required for the local current to excite the next node depends on the longitudinal resistance of the axoplasm, capacitance, and conductance of the intermodal membrane. With high value of these parameters, more current is dissipated before impulse reaches the next node. This results in longer time for the impulse to depolarize the adjacent node, which is responsible for the slower conduction. Myelin thickness is inversely related to internodal capacitance and conductance. Conduction velocity, therefore, increases with the increase in myelin to a certain point. In segmental demyelination or during remyelination, myelin sheath is thin, intermodal distance shorter, internodal conductance and capacitance is increased. These result in greater loss of local current before reaching the next node of Ranvier. The failure to activate the node of Ranvier results in conduction block. In case of a partial conduction, the impulse propagation is slowed due to longer time required by the dissipating current to generate an action potential. In segmental demyelination of smaller fibers the conduction may become continuous instead of saltatory. Impulse conduction in unmyelinated fibers occurs in a continuous manner which accounts for slower conduction velocity compared to saltatory conduction in myelinated fibers. The conduction velocity also slows down in focal compression, which may be due to demyelination and decrease in fiber diameter. (Mishra Kalita ,2006).The loss of myelin is associated with delayed or blocked conduction in the demyelinated axons. Normal conduction of action potentials relies on the insulating properties of myelin. Thus, defects in myelin can have major adverse neurological consequences. Loss of myelin leads to leakage of K+ through voltage-gated channels, hyperpolarization, and failure to conduct action potentials. Nerve conduction tests can detect slowed conduction in motor and sensory pathways. (Barrett et al., 2012) NERVE CONDUCTION STUDIES (NCS) The main indication of nerve conduction studies are for evaluation of paraesthesias (insensibility, creeping, fiery) or instability of the arms and legs. The type of study depends on symptoms presented. (Gutmann et al., 2003) NCS studies evaluate the dormancy, magnitude, as well as the pattern of the feedback following stimulation of the peripheral nerve through the skin and tissues by an electrical stimuli. The principle of nerve conduction studies (Mallik, Weir., 2005) In NCS we apply depolarizing electrical pulse square wave to the skin over a peripheral nerve generating a proliferate nerve action potential (NAP) recorded at a distant point over the same nerve. A compound  muscle action potential (CMAP) originating from the awaking of muscle grains in a destination muscle supplied by the nerve. These propagate nerve action potential and compound muscle action potential may be cited with surface or needle electrodes. Minor electrodes are restricted to allow around the full muscle stimulated, giving data for the time taken for the rapid axons to conduct an impulse to the muscle and the size of the feedback. Needle electrodes for NCS give authentic conduction time information, but because they evident from a small area of muscle or nerve it gives poor information and making numerical analysis difficult. Also it is difficult to obtain patient cooperation in an invasive technique. Nerves to be tested can either be stimulated through the skin with surface catalyst or it can be tested via a needle fixed close to the nerve or nerve roots. Choice of the stimulant depends on the desire to bracket above and below the  point of a prospective focal contusion and the anatomical opportunity to the applicable structure. (Mallik Weir et al., 2005). Motor nerve conduction performing motor nerve conduction study the surface electrodes overlying a muscle supplied by nerve to be tested is electrically stimulated and compound muscle action potential (CMAP) is recorded . The recording electrodes are fixed using sticky conducive pads placed in to the  overlying target muscle. The effective electrode is placed over the muscle belly and the reference electrode is situated over an electrically inactive site near by muscle tendon. A grounding electrode is placed between the electrodes maintaining a zero voltage reference point. The CMAP  is a calculated voltage response from an individual muscle fiber action potentials. The shortened inactivity of the CMAP is the time from stimulus  to the onset of action and it is a biphasic response with an initial upward deflection followed by a smaller downward deflection. The CMAP  amplitude is consistent from baseline to negative peak (the neurophysiological convention is that negative volta ge is demonstrated by an upward  deflection) and caculated in millivolts (mV) Figure-7: Compound Muscle Action Potential (CMAP) For recording CMAP, the stimulating current or voltage  is constantly increased until a point where there is no increment in CMAP amplitude. It is only at  supramaximal point that reproducible values for CMAP amplitude and the latency between the stimulus and the onset of the CMAP can be recorded  accurately. (Mishra Kalita, 2006) . The nerve is then excited at a more proximal site. In the normal state stimulating a nerve at  proximal site results in two CMAPs of similar shape and amplitude because the like motor axons innervate the muscle fibres making up the response  However, the latency will be greater for proximal stimulation compared with distal stimulation because of the longer distance between the stimulating  and documenting electrodes. The difference in inactivity represents the time taken for the fastest nerve fibre to conduct between the two stimulation  points as well as other factors involving neuromuscular transmission and muscle activation which is comm on to both stimulation sites. (MallikWeir  Gooch Pullman, 2005; Barboi Barkhaus,2004) . If we want to measures the distance between two sites then the fastest  can be calculated as follows: MNCV (m/s) = Distance between stimulation site 1 and site 2 (mm) [latency site 2 latency site 1  measurement the distance between 2 points of stimulation should be atleast10 cm. which reduces the error due to faulty distance  Stimulation at shorter segments of the nerve, however, is necessary in the evaluation of focal compression neuropathies e.g. CTS. Such short segment  stimulation does not allow the effect of focal slowing to be diluted by the unaffected nerve segment (Mishra Kalita, 2006) Sensory  StudiesThe sensory nerve action potential (SNAP) is achived by electrically stimulating sensory nerve fibres by a supra maximal stimulus and caculating the  nerve action potential at a point . Recording the SNAP orthodromically indicate to distal nerve stimulation and recording more  proximally (the direction in which physiological sensory conduction occurs). Recording the SNAP antidromically refers to proximal nerve stimulation  and recording more distally (opposite in order to the physiological sensory conduction occurs). Different laboratories have different antidromic or  orthodromic methods for testing different nerves. The acceleration correlates directly with the sensory latency, because the residual latency which  comprises neuromuscular transmission time and muscle propagation time is not applicable in sensory nerve conduction and therefore, either the results  may be expressed as latency over a standard distance, or acceleration. Only 20% largest diameter and fastest conducting sensory nerve fibres are  using in the conventional studies functionally supplying fine touch, vibration, and position sense. Predominantly small fibre neuropathies affecting  the 80% of fibres existing with prominent symptoms of pain and conventional studies .The various abnormal findings  are conduction slowing, conduction blockage, lack of responses,or low amplitude responses. NCV studies can acknowledge the degree of demyelination  and axonal loss in the segments of nerve examined. Demyelination of a nerve results in prolongation of conduction time (decreased conduction  velocity), where as axonal loss generally leads to the loss of nerve fiber and muscle potential amplitude. ( Mallik ,Weir., 2005)

Discuss Chaucers comic method in the Millers Prologue and Tale Essay

Discuss Chaucer's comic method in the Miller's Prologue and Tale. Combine your personal response with reference to other critical opinion at relevent points in your argument. The Miller's Tale is undoubtedly Chaucer's most crude and vulgar work, but how far did Chaucer intend for there to be a moral to his story? Are we supposed to sympathise with the jealous but 'sely' carpenter when the wife whom 'he lovede moore than his lyf' is unfaithful to him? Should we take pity on Absolon when his 'love-longynge' leads him to the riotous 'misplaced kiss'? We are warned not to 'maken ernest of game' in the Miller's Prologue, and we are also forewarned that the Miller's language and the content of the story may be offensive due to the ' ale of Southwerk'. By this point, it is clear that this is nothing but an amusing story, told purely for pleasure by a drunken and high-spirited miller. Elizabeth G. Melillo agrees in her essay that 'it seems a shame to do anything with the Miller's Tale except laugh heartily! To insert too much intellectual analysis may rob this, the best of 'dirty' stories of its charm.' Chaucer begins by preparing us for the trouble that is to come, by alerting us to the fact that the carpenter has married a woman much younger than him, and that 'his wit was rude' - he is an uneducated and gullible man, with a beautiful young wife. Dissatisfied with presenting us with the bare fact, Chaucer dedicates 40 lines to an elaborate description of Alisoun, in order to emphasise just how attractive she is. As Mc Daniel says, 'She is described in terms of a wily weasel, a vixen, a young calf; animalistic terms that emphasize her youthful sensuality'. By informing us of her 'likerous ye', Chaucer establ... ...ue not to 'maken ernest of game', and not to feel too sorry for the carpenter. The tale ends with the conclusion that 'swyvved was this carpenteris wyf, for al his kepyng and his jalousye'. Chaucer does not want us to take any moral from the tale, but it is packed full of them. It can be seen as a sort of sermon on the sins of pride and jealousy, hidden in the format of a 'naughty story'. According to McDaniel, 'the Miller tells this crude but hilarious story to remind the Host and all the other pilgrims that social pretense is dangerous'. Even though it may be difficult not to pity the carpenter at the end when he is hurt, cuckolded, and taunted, we must refrain from doing it. John Lippitt said that 'the tragic and the comic are not polar opposites, or mutually exclusive, but subtly and sometimes almost paradoxically inter-linked modes of experience'. Discuss Chaucer's comic method in the Miller's Prologue and Tale Essay Discuss Chaucer's comic method in the Miller's Prologue and Tale. Combine your personal response with reference to other critical opinion at relevent points in your argument. The Miller's Tale is undoubtedly Chaucer's most crude and vulgar work, but how far did Chaucer intend for there to be a moral to his story? Are we supposed to sympathise with the jealous but 'sely' carpenter when the wife whom 'he lovede moore than his lyf' is unfaithful to him? Should we take pity on Absolon when his 'love-longynge' leads him to the riotous 'misplaced kiss'? We are warned not to 'maken ernest of game' in the Miller's Prologue, and we are also forewarned that the Miller's language and the content of the story may be offensive due to the ' ale of Southwerk'. By this point, it is clear that this is nothing but an amusing story, told purely for pleasure by a drunken and high-spirited miller. Elizabeth G. Melillo agrees in her essay that 'it seems a shame to do anything with the Miller's Tale except laugh heartily! To insert too much intellectual analysis may rob this, the best of 'dirty' stories of its charm.' Chaucer begins by preparing us for the trouble that is to come, by alerting us to the fact that the carpenter has married a woman much younger than him, and that 'his wit was rude' - he is an uneducated and gullible man, with a beautiful young wife. Dissatisfied with presenting us with the bare fact, Chaucer dedicates 40 lines to an elaborate description of Alisoun, in order to emphasise just how attractive she is. As Mc Daniel says, 'She is described in terms of a wily weasel, a vixen, a young calf; animalistic terms that emphasize her youthful sensuality'. By informing us of her 'likerous ye', Chaucer establ... ...ue not to 'maken ernest of game', and not to feel too sorry for the carpenter. The tale ends with the conclusion that 'swyvved was this carpenteris wyf, for al his kepyng and his jalousye'. Chaucer does not want us to take any moral from the tale, but it is packed full of them. It can be seen as a sort of sermon on the sins of pride and jealousy, hidden in the format of a 'naughty story'. According to McDaniel, 'the Miller tells this crude but hilarious story to remind the Host and all the other pilgrims that social pretense is dangerous'. Even though it may be difficult not to pity the carpenter at the end when he is hurt, cuckolded, and taunted, we must refrain from doing it. John Lippitt said that 'the tragic and the comic are not polar opposites, or mutually exclusive, but subtly and sometimes almost paradoxically inter-linked modes of experience'.

History of Pole Dancing Essay

Pole dancing is a combination of dance and gymnastics that is an increasingly popular form of fitness and dance. Pole dancers use a vertical pole which is either static or spinning, and train in gyms or dedicated dance studios. It’s no secret that pole dancing really started in the strip clubs. But it has evolved into so much more and pole dancing fitness enthusiasts and schools have been working tirelessly to change the perception to one of a legitimate dance style emphasising the acrobatics and strength. Circus influences such as Chinese pole and other aerial arts have helped along the way, moving it away from the erotic environment. Competitions are usually non-sexual and are judged on tricks and transitions rather than sensuality. Rather than just the gyrating and grinding people expect it to be, pole dancing requires an amazing amount of strength, flexibility and cardiovascular endurance, even a five minute routine is extremely tiring! Obviously in clubs, rather than actual tricks, there is a lot of floor-work and other things that are designed to arouse rather than amaze! Pole dancers use upper body and core strength are the most obvious requirements as there are a lot of climbs, spins and inverting the body weight – it often involves a lot of training to get anywhere near an advanced level. Pole dancing as we see it today originated during the depression in America. The traveling entertainment and carnival troupes would go from town to town. In one of the side tents aside from the main show, girls would dance suggestively on a small stage in front of crowds of cheering men. Sound familiar? Pole dancing gradually moved into to bars in the 1950s as burlesque became more popular and then during the 1980s in North America, became pole dancing and the modern striptease. It was only a decade later that a dancer in Canada started teaching pole dancing for fitness to women who weren’t club dancers. In Australia, the first pole dancing studio, Bobbi’s Pole Studio, opened in Sydney in 2004, closely followed by Pole Divas in Melbourne in 2004 and a national competition followed in 2005. Since then there have been dozens of pole dancing schools opening all over Australia and we boast some of the best pole dancers in the world, including multiple Miss Pole Dance World winner, Felix Cane. We do know that there are different styles of pole dancing including Chinese pole, and Mallakhamb (an Indian sport), neither of which have an erotic component and are mainly performed by men, so obviously pole dancing in different forms has developed around the world over time. The Mallakhamb pole is wide, made of wood and has a wooden ball on the top of it. Chinese Pole is usually performed using two poles, between which the men perform gravity defying acrobatics. During a pole dancing fitness class, which are often similar to aerobics or dance classes in their format, students begin with a cardiovascular warm up, use dynamic stretching and strength drills to prepare and then learn a series of tricks, climbs and inverts and often then put them into a dance routine to practice transitions and develop their endurance. One other thing that is often reported by women who have taken up pole dancing for fitness is a feeling of empowerment and increased confidence. Whether this is because of their developing strength, skill, grace or simply a sense of achievement, differs from student to student. Pole dancing now focuses on the fitness, acrobatics and dance performance aspects and competitions are fierce. Some dancers are lean contortion machines whilst some look like they could be body builders in their spare time. Women and men compete on a regular basis around the world in a number of styles, all with absolutely breathtaking performances. Pole dancing has definitely come a long way from the sexy tent pole dancing where it began!

Learned Interpretation essays

Learned Interpretation essays In her book, "Justice and Interpretation", Georgia Warnke sets forth the general principles of hermeneutics. Hermeneutics is basically another way of referring to the way we as a society interpret various information through our history and culture. It is the way we give reasons why a particular decision or action was appropriate for us at a given time. Warnke also illustrates how hermeneutics can be beneficial to our society. In the conclusion of her book, she discusses the debate on abortion and shows how a hermeneutic approach to the debate can be beneficial to both sides. First, she makes the point that a hermeneutic approach can, shift the emphasis from a conflict, that between the advocates of pro-choice and those of pro-life, to a conflict between two interpretations of how the decisions and actions taken by each group followed along the guidelines set forth by the traditions of our society. Through this change, the conflict becomes one, not over which group is correct in its thinking, but one in which the integrity of our society as a whole can be examined. This change will, in turn, help to reduce the tension between the opposing forces and help them to more effectively reach a resolution that will best represent the feelings of the entire society. The problem that arises here is that the opposing sides may, and often do have opposing conceptions of just how a society can define what is most appropriate for it. Here again, she uses the debate over abortion to illustrate her point. She states that for the pro-life position, banning all abortions may be the only action consistent with the traditions of the society we live in, and that for the pro-choice position, protecting the possibility of abortion as a constitutional right is the only plausible action for the same reasons. She explains how there is no conceivable way o ...

John Coltrane essays

John Coltrane essays Jazz, taking its roots in African American folk music, has evolved, metamorphosed, and transposed itself over the last century to become a truly American art form. More than any other type of music, it places special emphasis on innovative individual interpretation. Instead of relying on a written score, the musician improvises. For each specific period or style through which jazz has gone through over the past seventy years, there is almost always a single person who can be credited with the evolution of that sound. From Thelonius Monk, and his bebop, to Miles Davis cool jazz, from Dizzy Gillespies big band to John Coltranes free jazz; Americas music has been developed, and refined countless times through individual experimentation and innovation. One of the most influential musicians in the development of modern jazz is John Coltrane. In this paper, I examine the way in which Coltranes musical innovations were related to the music of the jazz greats of his era and to the trib ulations and tragedies of his life. John William Coltrane was born in Hamlet, North Carolina, on September 23, 1926. Two months later, his family moved to High Point, North Carolina, where he lived in a fairly well-to-do part of town. He grew up in a typical southern black family, deeply religious, and steeped in tradition. Both of his parents were musicians, his father played the violin and ukulele, and his mother was a member of the church choir. For several years, young Coltrane played the clarinet, however with mild interest. It was only after he heard the great alto saxophonist Johnny Hodges playing with the Duke Ellington band on the radio, that he became passionate about music. He dropped the clarinet and took up the alto saxophone, soon becoming very accomplished. When Coltrane was thirteen, he experienced several tragedies that would leave a lasting impression on him and would have a great impact on the mus...

Drugs and Control Substances among Hispanic Cultures Research Paper

Drugs and Control Substances among Hispanic Cultures - Research Paper Example Marijuana and cocaine use among eighth-grade students increased during the years 1991to 2002 according to samples obtained from the MTF. Despite this, there has been a decline in the use of both marijuana and cocaine among the Hispanics for the past few years. However, the Hispanic groups have depicted a higher rate of marijuana abuse compared to other groups such as whites and blacks. Therefore, the high rates of drug abuse among young Hispanic individuals have led to an increased threat to the public health because it contributes to a significant risk of addiction problems. Alvarez, Jason, Olson, Ferrari & Davis (2007) explains that Hispanic cultures in relation to drugs and control substances can be expressed in terms of the gender differences depicted through prevalence rates of drugs substances abused. In fact, these differences are profound among the Latinos and Latinas, whereby the former has increased likelihood of abstaining from abusing drugs and other control substances compared to the latter (Cervantes & Pena, 1998). There are notions from various researchers indicating that this tendency is caused by their cultural norms, which do not support substance use among women. In this case, the Latinas are protected from the effects of drug abuse and substances through a promotion of abstinence. Moreover, empirical evidence has justified the interrelationship between American cultural values and drug abuse among the Latinas. For instance, a national survey indicated that over one thousand Latinas depicted their interaction with non-Latinos and held their cultural values have reduced chances of abstaining from abusing drugs.

Worldview as it Relates to Philosophy Research Paper

Worldview as it Relates to Philosophy - Research Paper Example Through experience and education individuals develop these perspectives and implement them as a means of living their daily existence. When considering myself I recognize that my worldview has changed drastically over the course of my life and has been greatly influenced by experience and philosophy. This essay considers my current worldview and the way my past worldview has been influenced and changed through philosophy. Before taking this course my worldview was strongly rooted in religious doctrines. Throughout the formative periods of my life I grew up in an environment that was strictly Christian. Within this environment my parents and most of my peers believed in the major tenants of the Christian religion. Growing up in this environment I learned to adopt most of the religious principles that are espoused by the Christian religion. In terms of the creation of the world I believed that Earth and the universe had been created by God. I believed in morals as they related to the c oncept of good and evil as established by the Bible. In these regards, morality was presented as an easily understandable concept – if an individual adhered to the law and the tenants of the Bible then they were a moral and good person. I also embraced a concept of the afterlife. If individuals adhered to the Biblical principles and allowed God into their life then I believed they would go to heaven. Conversely, if they disregarded these aspects, they would go to Hell. My relation to science and logic were complex. While I embraced the principle of science in an overarching sense, I came to believe that oftentimes science could be wrong or mistaken. Specifically, in terms of evolution and cosmology I believed that while scientists had approached the concepts of existence and biology with their greatest ability, they were ultimately flawed in their findings. I understood that that ultimately their current scientific investigations would be proven wrong and they would ultimatel y discover that God and Biblical principles were the true reality of existence. When I look back on my worldview during this period of my life I recognize that I was greatly influenced by my personal surroundings and parents’ influence. As I gradually became more exposed to new ideas and new people my worldview drastically changed. In large part, the philosophical ideas I was exposed to in this course shaped and sharpened my worldview in a variety of ways. One of the major notions that I came to recognize through my research in philosophy emerged in terms of Christian morality. While Christianity noted that there were easily understood concepts of good and evil, my exposure to philosophers such as Friedrich Nietzsche in Beyond Good and Evil led me to understand that moral actions couldn’t easily be broken down into concepts of ‘good’ and ‘evil’ but often involve a complex number of philosophical implications (Nietzsche 1993). Another profound such changes that I experienced occurred in my understanding and eventual embracement of scientific principles. As I previously indicated that I had believed science did not properly understand Christian understandings of the world, as I became exposed to more scientific thought I came to understand that in large part the principles behind such concepts as evolution are supported by substantial scientific research. In these regards, I learned to increasingly embrace the notion that many of the claims made in the Bible may be wrong. As I became exposed to earlier notions of mythology, such as the Epic of Gilgamesh, which contains a flood story, I further came to recognize